Mass Effect 2 Wiki Walkthrough: Mission Order, Dialogue Choices & Tips
This guide page for Mass Effect 2’s wiki walkthrough covers the core storyline missions, designed to help you move cleanly from combat encounters to collectible locations and the right dialogue picks. It’s built to support a full playthrough focused on making progress efficiently while still setting you up for the best outcomes.
You can use it in two ways: a text-and-pictures layout, or video demonstrations for the same sections. If you’re looking for a specific mission beat or phase of the run, there are jump links laid out for quick navigation.
Jump to:
- Prologue
- Assemble a Team: Part 1
- Assemble a Team: Part 2
- Loyalty Missions
- The Suicide Mission
Even though this portion of the guide is meant to cover what you need to clear the game, every walkthrough, assignment, and downloadable content page includes links that connect into a complete 100% route. That larger plan is called the Full Walkthrough Roadmap.
- Full Walkthrough Roadmap
About a month after the defeat of Sovereign in Mass Effect 1, Commander Shepard and the Normandy crew begin searching the galaxy for the last remaining Geth strongholds. The campaign takes a sudden turn when they encounter Cerberus and learn that Reaper agents are already spreading terror among humanity—before they even fully arrive.
Prologue
To take down the Collectors, Shepard must push through the Omega-4 Relay in order to hit the Collectors at their base—an operation described as effectively suicidal. To give Shepard the best possible chance, the Illusive Man tasks them with traveling and building an elite team capable of completing the mission.
Assemble a Team: Part 1
After a reunion in the colony of Horizon, the Illusive Man sends Shepard three additional dossiers. The goal is to recruit a set of highly skilled specialists to round out the team before the operation against the Collectors begins.
Assemble a Team: Part 2
Recruitment is only part of the job. Shepard also needs to address the personal and psychological state of the crew, since unresolved “old ghosts” from the past can resurface. The guide emphasizes that the team must be at their best if Shepard wants any realistic path to defeating the Collectors.
Loyalty Missions
Once the team is in place, Shepard boards an extremely risky craft to retrieve a device that could make the Omega-4 Relay passable. Unfortunately, events take a turn for the worse, escalating the stakes until Shepard is forced to make the jump straight to the Collector base of operations.
The Suicide Mission
Want additional support beyond this mission outline? The guide points readers toward several adjacent pages that cover changes, decision-making, and relationship content, plus more detailed walkthrough help.
- Legendary Edition Changes
- How-To Guides
- Key Choices and Consequences
- Romance Options
- Walkthrough
- Side Quests
Quick facts
- The guide is a walkthrough of Mass Effect 2’s main storyline missions, covering combat, collectibles, and dialogue decisions.
- It’s available in both text-and-pictures and video demonstration formats.
- It links into a 100% completion plan called the Full Walkthrough Roadmap.
- The story begins about a month after Sovereign’s defeat in Mass Effect 1 and introduces Cerberus and Reaper terror.
- The Collectors plan centers on using the Omega-4 Relay and assembling an elite team.
Up Next: Full Walkthrough Roadmap
Top Guide Sections
- Legendary Edition Changes
- Basics
- Tips and Tricks
- How-To Guides
