Mass Effect 2 Prologue Guide: Combat Tips, Loot Routes, Dialogue Choices

Mass Effect 2’s wiki guide section kicks off with a focus on the game’s earliest events—covering how to push through the prologue combat, track down loot, and select dialogue options that shape your commander’s first stretch of the story.

What this section covers

This part of the Mass Effect 2 wiki guide zeroes in on the Prologue, walking you through getting through every combat encounter in that opening stretch, pointing out where to find loot sources, and advising on which dialogue choices to make for your specific playthrough.

Mass Effect 2 Prologue overview

Mass Effect 2 begins with a prologue sequence before you ever reach character creation, because the character creator is presented as part of the overarching narrative. Even if you imported a save from Mass Effect 1, you’ll still be able to adjust Commander Shepard’s appearance in this entry.

From there, the guide transitions into the game’s first real opening missions, where Shepard learns about a new threat and meets the people who can help them stop it.

It also includes a handful of extra sections that aren’t labeled with the Prologue prefix, but still function as prelude material—essentially covering the period before the game fully opens up. The guide additionally folds in shopping stops at The Citadel and Omega, since Mass Effect 1 players typically arrive with credits to spend, and there aren’t many other convenient places to use them.

Prologue mission listing and related guide links

Here are the missions which form the Prologue:

Want even more Mass Effect 2 support? The guide points readers to additional pages, including:

  • Legendary Edition Changes
  • How-To Guides
  • Key Choices and Consequences
  • Romance Options
  • Walkthrough
  • Side Quests

Up Next: Prologue – Save Joker

Top Guide Sections

  • Legendary Edition Changes
  • Basics
  • Tips and Tricks
  • How-To Guides

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Marcus Chen is a gaming journalist and industry reporter with more than 10 years of experience. He covers releases, announcements, and trends across PC, PlayStation, Xbox, and Nintendo, and keeps a close eye on the indie scene and esports. Previously an editor at several gaming publications, he now writes news, reviews, and breakdowns of major industry moments—from big showcases to updates on popular titles. His work is aimed at players who want a clear, fast read on what happened and why it matters.